VICOMER™ RNA Modulating Platform
✅ Multiple RNA modulating mechanisms of action
✅ Precision chemistry for optimal efficacy and safety
✅ Reversible and transient in nature
✅ No permanent changes to DNA code
Multiple modalities to modulate RNA
VICOMER is a platform for antisense oligonucleotide designed to modulate RNA. Modulating approaches include translation, splicing, editing, degradation, and activation.
We select a specific type of RNA modulator best suited to correct the genetic defect and apply precision chemistry to achieve the desired efficacy and safety profile.
RNA is in our DNA
Our platform technology is built on our significant experience in designing, manufacturing and developing antisense oligonucleotides as RNA modulating therapeutics.
Our antisense oligonucleotides are simple synthetic but biodegradable stretches of nucleotides that allow high sequence-specificity, straightforward optimization of structure activity relationship, and finetuned implementation of state-of-the-art chemical modifications.
Lowering levels of toxic proteins by binding to mature mRNA to sterically hinder ribosomal translation initiation and/or elongation.
Restore protein function and correct the translational open reading frame by binding to splice-regulatory sequences in pre-mRNA to sterically hinder the splicing machinery and induce exon skipping or exon inclusion.
Restore protein function by binding to certain disease-causing mutations in (pre)mRNA to guide and recruit endogenous enzymes that are naturally capable of changing/correcting a specific nucleotide such as adenosine or cytosine deaminases.
Reducing levels of transcripts encoding toxic proteins by binding to a specific sequence-stretch in target (pre)mRNAs to recruit RNaseH